By Kaleigh - August 1, 2016, Updated April 13, 2022

Healthy Greek Chicken with Tzatziki Sauce

Name: Healthy Greek Chicken with Tzatziki Sauce
Prep time: 40 min
Cook time: 20 min
Total time: 1 h
Cuisine: Greek
Ingredients: 1 tsp salt; 2 tsp garlic powder; 1 tsp onion powder; 2 tsp dried basil; 2 tsp dried Greek oregano; 2 tsp paprika; 1 tsp freshly ground black pepper; 1 tsp dried rosemary, minced; 1 tsp dried dill; 1 tsp dried marjoram; 1/2 tsp ground thyme; 1/2 tsp ground nutmeg; Juice of 2 large lemons; 2 tbsp red wine vinegar; 2 tbsp olive oil; 4 tbsp Greek seasoning; 2 large boneless, skinless chicken breast; 1/4 medium cucumber; 1 cup plain Greek yogurt; 2 cloves garlic, minced; 2 tbsp chopped fresh dill; Juice of 1/2 lemon; 1/8 tsp salt; Pinch black pepper

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Make this flavorful Greek chicken with tzatziki sauce tonight! Tender Greek seasoned chicken breasts with cool, creamy Tzatziki sauce is a delicious, easy and healthy dinner with Mediterranean inspiration. (gluten-free, nut-free)

overhead view of healthy Greek chicken with tzatziki sauce on top and pasta salad next to it on a white plate.

When I need a solid, healthy dinner that I know everyone will love, I always turn to this Greek chicken recipe! It's one of my family's favorite dinners, and I often take it to friends who have babies or need a homemade dinner for some reason or another. Everyone always raves about it! It features the most delicious homemade Greek seasoning, easy grilled chicken breasts, and a flavorful, creamy tzatziki sauce to serve with it. Luckily, the seasoning recipe makes a lot, so you can put this recipe on your menu often!

Why You'll Love This Greek Chicken with Tzatziki

I'm the kind of person who prefers not to buy a ton of seasoning blends. I like to make my own so I can control the flavors and the salt level. It's also so easy to make your own and always tastes better! This Greek seasoning is no different. It makes the most flavorful coating for chicken breasts, along with a simple marinade. Once the seasoning is made, the rest comes together quickly - you can make the tzatziki while the chicken marinades and prep the rest of your dinner. This dinner is filling and satisfying. And since the sauce is made with protein-rich Greek yogurt, it's still light and healthy!

The Ingredients

overhead view of ingredients needed to make greek chicken.

Boneless, skinless chicken breasts
Greek seasoning - keep reading for my homemade seasoning!
Red wine vinegar
Lemon juice
Olive oil

For the Tzatziki sauce, you'll need:

Cucumber
Plain Greek yogurt
Lemon juice
Garlic
Dill
Salt & Pepper

How To Make It

4 image collage showing steps for making greek chicken.

Make The Greek Seasoning

Mix all the spices together in a jar (so you can store the extra for later!).

Make the Chicken

Butterfly the chicken breasts in half so you have four cutlets of even thickness.
Sprinkle the chicken liberally with the seasoning. Add the lemon juice, red wine vinegar and olive oil and turn it to coat evenly. Marinate the chicken for at least 30 minutes.
Grill the chicken on the grill or in a grill pan over medium heat for 8-10 minutes per side (more or less depending on the thickness of the chicken).

three image collage showing steps for making tzatziki sauce.

Make the Tzatziki Sauce

While the chicken is marinating, grate the cucumber onto a clean cloth, paper towel, or fine mesh strainer. Squeeze out as much liquid as possible and discard the liquid.
Place the cucumber in a bowl and add the yogurt, garlic, dill, lemon juice, salt and pepper. Stir to combine.
Refrigerate the sauce until you're ready to serve your chicken.

Tips for Perfect Chicken with Tzatziki

Time is not the best indicator for determining chicken doneness, especially when thickness can vary. I always recommend a meat thermometer to determine when chicken is done to avoid drying it out - or food poisoning. Chicken is done when the thickest part reaches 165°F.
Marinate the chicken for at least 30 minutes for the best flavor, but avoid going over a few hours since the liquid is pretty acidic and will start to denature the proteins on the chicken. It's not a big deal, but it does happen if the chicken sits in the marinade for a long time.
I like to grate the garlic for the tzatziki since I already have the grater out for the cucumber. Always remember fresh garlic is best!
If you don't have fresh dill, you can substitute half to 1 teaspoon of dried dill for the sauce. It won't be as good, but will work in a pinch.
If you're short on time (or spices!) you can use store-bought Greek seasoning instead of making your own.

healthy Greek chicken with tzatziki sauce on top, pasta salad next to it on a white plate.

Can It Be Made In Advance?

The tzatziki sauce can absolutely be made in advance. In fact, it tastes best when made 1-2 hours ahead of time so the flavors can meld. You can make tzatziki up to 2 days in advance. Just know that the garlic gets stronger over time.
The Greek seasoning can also be made in advance and stored in your spice cabinet for up to 3 months.
You can marinate the chicken for up to 2 hours. You can also cook it in advance if you'd like to eat the chicken cold - such as in a wrap for lunch or if you like to meal prep. I don't love chicken reheated, but it will stay good in the refrigerator for 3-4 days.

Can The Chicken Be Baked?

Yes! If you don't have a grill, bake the chicken at 375°F for 15-20 minutes or until the internal temperature reaches 165°F.

What To Serve with Greek Chicken

You can serve this chicken sliced on a pita or flatbread to make a gyro-style wrap (like my lamb souvlakis here!). Of keep it lower carb with a lettuce wrap if you'd rather.
Serve on top of a Greek salad or simple bed of greens - try my homemade Greek Dressing!
Serve with Easy Oven Broiled Asparagus or Simple Sautéed Green Beans and quinoa to keep things simple.
If you want to make the side dish pictured here, I now have the recipe on the blog - Healthy Greek Orzo Pasta Salad with Homemade Dressing.
Serve it on a bowl, like these Greek Chicken Grain Bowls.

Did you make this recipe? Please leave a star rating in the comments!