Healthy Greek Chicken with Tzatziki Sauce

overhead view of Healthy Greek Chicken with Tzatziki Sauce on a plate with greek orzo salad and a gold fork.

4.9 from 10 reviews

Make this flavorful Greek chicken with tzatziki sauce tonight! Tender Greek seasoned chicken breasts with cool, creamy Tzatziki sauce is a delicious, easy and healthy dinner with Mediterranean inspiration. (gluten-free, nut-free)



Greek Seasoning:

  • 1 tsp salt
  • 2 tsp garlic powder
  • 1 tsp onion powder
  • 2 tsp dried basil
  • 2 tsp dried Greek oregano
  • 2 tsp paprika
  • 1 tsp freshly ground black pepper
  • 1 tsp dried rosemary, minced
  • 1 tsp dried dill
  • 1 tsp dried marjoram
  • 1/2 tsp ground thyme
  • 1/2 tsp ground nutmeg

Greek Chicken:

  • Juice of 2 large lemons
  • 2 tbsp red wine vinegar
  • 2 tbsp olive oil
  • 4 tbsp Greek seasoning
  • 2 large boneless, skinless chicken breast

Tzatziki Sauce:

  • 1/4 medium cucumber
  • 1 cup plain Greek yogurt
  • 2 cloves garlic, minced
  • 2 tbsp chopped fresh dill
  • Juice of 1/2 lemon
  • 1/8 tsp salt
  • Pinch black pepper


  1. To make Greek seasoning, mix all spices together. It will make about 1/2 cup. Set aside for later.
  2. For the chicken, butterfly boneless, skinless chicken breasts into 2 pieces of even thickness each. Rub Greek seasoning evenly over chicken. Place in a shallow dish or large plastic bag with lemon juice, red wine vinegar and olive oil. Let marinate for at least 30 minutes.
  3. While chicken is marinating, prepare the Tzatziki sauce. Grate the cucumber (you can peel it but I don't) onto a mesh strainer or paper towel and squeeze out as much liquid as you can, discarding the liquid. Add cucumber to a bowl with yogurt, garlic, dill, lemon juice, salt and pepper. Stir to combine and refrigerate until ready to serve.
  4. Grill the chicken. Preheat grill or grill pan to medium-high heat.
  5. Remove chicken from the marinade and grill for 8-10 minutes per side, or until a thermometer inserted in the center reads 165°F.
  6. Remove chicken from the grill and serve with Tzatziki sauce.


  • You can also bake chicken in a baking dish at 375°F for 15-20 minutes, or until the juices run clear.
  • Time is not the best indicator for determining chicken doneness, especially when thickness can vary. I always recommend a meat thermometer to determine when chicken is done to avoid drying it out - or food poisoning. Chicken is done when the thickest part reaches 165°F.
  • The seasoning makes plenty to use for later! Store in an airtight container at room temperature.
  • Tzatziki can be made up to a day in advance. For a more detailed guide, see my  full recipe post for tzatziki sauce.

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